多能胚胎干细胞中的染色质与分化。
Chromatin in pluripotent embryonic stem cells and differentiation.
作者信息
Meshorer Eran, Misteli Tom
机构信息
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Nat Rev Mol Cell Biol. 2006 Jul;7(7):540-6. doi: 10.1038/nrm1938. Epub 2006 May 17.
DOI:10.1038/nrm1938
PMID:16723974
Abstract
Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.
摘要
胚胎干细胞（ES细胞）的独特之处在于它们具有多能性且能够自我更新。构成这两个基本特性的分子机制在很大程度上尚不清楚。我们将探讨ES细胞中染色质的独特特性如何有助于维持多能性以及决定分化特性。
Zotero 插件