复杂疾病遗传学中的流行病学考量

Epidemiologic considerations in complex disease genetics.

作者信息

Gallacher John

出版信息

Cold Spring Harb Protoc. 2012 Jan 1;2012(1):62-70. doi: 10.1101/pdb.top067512.

PMID:22194262

Abstract

Association studies are becoming an increasingly popular study design not only for testing of candidate genes, but also for genome-wide localization of loci influencing complex disease. This article covers some of the practical concerns in conducting large-scale association studies using epidemiologic samples.

摘要

关联研究正日益成为一种流行的研究设计，不仅用于检测候选基因，还用于全基因组定位影响复杂疾病的基因座。本文涵盖了使用流行病学样本进行大规模关联研究时的一些实际问题。