基因关联研究导论。
Introduction to genetic association studies.
作者信息
Lewis Cathryn M, Knight Jo
出版信息
Cold Spring Harb Protoc. 2012 Mar 1;2012(3):297-306. doi: 10.1101/pdb.top068163.
PMID:22383645
Abstract
Genetic association studies are used to find candidate genes or genome regions that contribute to a specific disease by testing for a correlation between disease status and genetic variation. This article provides a broad outline of the design and analysis of such studies, focusing on case-control studies in candidate genes or regions.
摘要
基因关联研究用于通过检测疾病状态与基因变异之间的相关性，来寻找与特定疾病相关的候选基因或基因组区域。本文概述了此类研究的设计与分析，重点关注候选基因或区域中的病例对照研究。
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