Gasparian G G, Grigorian R M, Sarkisian N K
Tsitologiia. 1990;32(3):227-31.
As was reported elsewhere (Gasparian, Grigorian, 1989a, 1989b), the stimulation of cell proliferation takes place in established culture of chick embryo cells after adding a suspension of living or inactivated homologous cells. In the present paper the kinetic parameters of this process, termed as the contact stimulation of cell proliferation, were studied. The dose- and time-dependence of cell response to the stimulus is described. It was shown that the addition of cells activates cell growth both in exponential and stationary cultures. DNA synthesis in resting cells is seen initiated only if their continuous interaction with the added cells is provided. The nature of signals involved in the process of contact stimulation is described.
正如其他地方所报道的（加斯帕里安，格里戈里安，1989a，1989b），在添加活的或灭活的同源细胞悬液后，鸡胚细胞的既定培养物中会发生细胞增殖刺激。在本文中，研究了这个被称为细胞增殖接触刺激过程的动力学参数。描述了细胞对刺激反应的剂量和时间依赖性。结果表明，添加细胞会激活指数生长期和静止期培养物中的细胞生长。只有当静止细胞与添加的细胞持续相互作用时，才会观察到静止细胞中的DNA合成启动。描述了参与接触刺激过程的信号性质。
