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一种用于大流行性流感模拟的基于云的模拟架构。

A cloud-based simulation architecture for pandemic influenza simulation.

作者信息

Eriksson Henrik, Raciti Massimiliano, Basile Maurizio, Cunsolo Alessandro, Fröberg Anders, Leifler Ola, Ekberg Joakim, Timpka Toomas

机构信息

Dept. of Comp. and Inform. Sci., Linköping University, Sweden.

出版信息

AMIA Annu Symp Proc. 2011;2011:364-73. Epub 2011 Oct 22.

PMID:22195089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3243184/
Abstract

High-fidelity simulations of pandemic outbreaks are resource consuming. Cluster-based solutions have been suggested for executing such complex computations. We present a cloud-based simulation architecture that utilizes computing resources both locally available and dynamically rented online. The approach uses the Condor framework for job distribution and management of the Amazon Elastic Computing Cloud (EC2) as well as local resources. The architecture has a web-based user interface that allows users to monitor and control simulation execution. In a benchmark test, the best cost-adjusted performance was recorded for the EC2 H-CPU Medium instance, while a field trial showed that the job configuration had significant influence on the execution time and that the network capacity of the master node could become a bottleneck. We conclude that it is possible to develop a scalable simulation environment that uses cloud-based solutions, while providing an easy-to-use graphical user interface.

摘要

大流行疫情的高保真模拟消耗资源。已有人建议采用基于集群的解决方案来执行此类复杂计算。我们提出了一种基于云的模拟架构,该架构利用本地可用的计算资源以及在线动态租用的计算资源。该方法使用Condor框架来进行作业分发以及管理亚马逊弹性计算云(EC2)和本地资源。该架构具有基于网络的用户界面,允许用户监控和控制模拟执行。在一次基准测试中,EC2 H-CPU 中型实例记录了最佳的成本调整性能,而一次现场试验表明作业配置对执行时间有重大影响,并且主节点的网络容量可能成为瓶颈。我们得出结论,开发一个使用基于云的解决方案并提供易于使用的图形用户界面的可扩展模拟环境是可行的。

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本文引用的文献

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Requirements and design of the PROSPER protocol for implementation of information infrastructures supporting pandemic response: a Nominal Group study.PROSPER 协议的需求和设计,用于实施支持大流行应对的信息基础设施:名义小组研究。
PLoS One. 2011 Mar 28;6(3):e17941. doi: 10.1371/journal.pone.0017941.
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Studies needed to address public health challenges of the 2009 H1N1 influenza pandemic: insights from modeling.需要研究解决 2009 年 H1N1 流感大流行带来的公共卫生挑战:建模的启示。
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Assumptions management in simulation of infectious disease outbreaks.传染病暴发模拟中的假设管理
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Impact of precautionary behaviors during outbreaks of pandemic influenza: modeling of regional differences.甲型H1N1流感大流行期间预防行为的影响:区域差异建模
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BMC Med. 2009 Dec 10;7:76. doi: 10.1186/1741-7015-7-76.
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Publication guidelines for quality improvement studies in health care: evolution of the SQUIRE project.医疗保健质量改进研究的出版指南:SQUIRE项目的演变
BMJ. 2009 Jan 19;338:a3152. doi: 10.1136/bmj.a3152.
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The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies.《流行病学观察性研究报告强化(STROBE)声明》:观察性研究报告指南
Lancet. 2007 Oct 20;370(9596):1453-7. doi: 10.1016/S0140-6736(07)61602-X.
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Ontology based modeling of pandemic simulation scenarios.
Stud Health Technol Inform. 2007;129(Pt 1):755-9.
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A discrete time-space geography for epidemiology: from mixing groups to pockets of local order in pandemic simulations.一种用于流行病学的离散时空地理学:从混合群体到疫情模拟中的局部秩序区域
Stud Health Technol Inform. 2007;129(Pt 1):464-8.