Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany.
Org Lett. 2012 Jan 20;14(2):656-9. doi: 10.1021/ol203353a. Epub 2011 Dec 23.
An efficient Rh(III)-catalyzed direct C-H amination of N-pivaloyloxy benzamides with N-chloroamines proceeding at room temperature was achieved. The versatile directing group allows for selective mono- and diamination and can be readily converted to give valuable benzamide or aminoaniline derivatives. Mechanistic studies have been carried out to elucidate the reaction pathway.
一种高效的 Rh(III)催化室温下 N-特戊酰氧基苯甲酰胺与 N-氯代胺的直接 C-H 氨化反应已经实现。这种多功能导向基团允许选择性的单氨化和双氨化，并可以很容易地转化为有价值的苯甲酰胺或苯胺衍生物。已经进行了机理研究以阐明反应途径。
