Buerk Donald G, Barbee Kenneth A, Jaron Dov
Drexel University, Philadelphia, PA, USA.
Crit Rev Biomed Eng. 2011;39(5):397-433. doi: 10.1615/critrevbiomedeng.v39.i5.40.
Several apparent paradoxes are evident when one compares mathematical predictions from models of nitric oxide (NO) diffusion and convection in vasculature structures with experimental measurements of NO (or related metabolites) in animal and human studies. Values for NO predicted from mathematical models are generally much lower than in vivo NO values reported in the literature for experiments, specifically with NO microelectrodes positioned at perivascular locations next to different sizes of blood vessels in the microcirculation and NO electrodes inserted into a wide range of tissues supplied by the microcirculation of each specific organ system under investigation. There continues to be uncertainty about the roles of NO scavenging by hemoglobin versus a storage function that may conserve NO, and other signaling targets for NO need to be considered. This review describes model predictions and relevant experimental data with respect to several signaling pathways in the microcirculation that involve NO.
当人们将血管结构中一氧化氮（NO）扩散和对流模型的数学预测与动物和人体研究中NO（或相关代谢物）的实验测量结果进行比较时，几个明显的悖论就显而易见了。数学模型预测的NO值通常远低于文献中报道的体内实验NO值，特别是在微循环中不同大小血管旁的血管周围位置放置NO微电极，以及将NO电极插入所研究的每个特定器官系统微循环供应的各种组织中时。关于血红蛋白清除NO与可能保存NO的储存功能的作用仍存在不确定性，并且需要考虑NO的其他信号靶点。本综述描述了关于微循环中涉及NO的几种信号通路的模型预测和相关实验数据。
