Department of Biomedical Engineering, Florida International University, Miami, FL, USA.
Wiley Interdiscip Rev Syst Biol Med. 2011 Jan-Feb;3(1):93-106. doi: 10.1002/wsbm.97.
Calcium is a universal signaling molecule with a central role in a number of vascular functions including in the regulation of tone and blood flow. Experimentation has provided insights into signaling pathways that lead to or affected by Ca(2+) mobilization in the vasculature. Mathematical modeling offers a systematic approach to the analysis of these mechanisms and can serve as a tool for data interpretation and for guiding new experimental studies. Comprehensive models of calcium dynamics are well advanced for some systems such as the heart. This review summarizes the progress that has been made in modeling Ca(2+) dynamics and signaling in vascular cells. Model simulations show how Ca(2+) signaling emerges as a result of complex, nonlinear interactions that cannot be properly analyzed using only a reductionist's approach. A strategy of integrative modeling in the vasculature is outlined that will allow linking macroscale pathophysiological responses to the underlying cellular mechanisms.
钙是一种普遍的信号分子，在许多血管功能中起着核心作用，包括调节张力和血流量。实验为导致或受血管内钙动员影响的信号通路提供了深入了解。数学模型为分析这些机制提供了一种系统的方法，并且可以作为数据解释和指导新的实验研究的工具。一些系统（如心脏）的钙动力学综合模型已经非常先进。这篇综述总结了在血管细胞中钙动力学和信号转导建模方面的进展。模型模拟表明，钙信号是如何作为复杂的非线性相互作用而出现的，仅使用简化方法是无法对其进行适当分析的。概述了一种血管内综合建模策略，该策略将允许将宏观病理生理学反应与潜在的细胞机制联系起来。
