Pappadopulos Elizabeth, Rosato Nancy Scotto, Correll Christoph U, Findling Robert L, Lucas Judith, Crystal Stephen, Jensen Peter S
Center for the Advancement of Children's Mental Health, Columbia University, New York, New York, USA.
J Child Adolesc Psychopharmacol. 2011 Dec;21(6):505-15. doi: 10.1089/cap.2010.0128.
Psychiatric treatment for children and adolescents with clinically significant aggression is common and often involves the use of antipsychotic medications. Increasingly, pediatricians are initiating or managing such treatments despite limited evidence on optimal diagnostic, psychosocial, and medication approaches for pediatric aggression.
The objective of this study was to gather clinicians' and researchers' expertise concerning the treatment of maladaptive aggression, using expert consensus survey methods to aid the development of guidelines for pediatricians and psychiatrists on the outpatient treatment of maladaptive aggression in youth (T-MAY).
Forty-six experts (psychiatrists, pediatricians, and researchers) with >10 years of clinical and/or research experience in the treatment of pediatric aggression completed a 27-item survey (>400 treatment alternatives) about optimal diagnostic, psychosocial, and medication treatments. Data were analyzed using descriptive statistics and confidence intervals.
Expert consensus methodology clearly differentiated optimal versus nonoptimal treatment strategies for maladaptive aggression. In contrast to current practice trends, results indicated that experts support the use of psychosocial interventions and parent education and training before the use of medication for maladaptive aggression at every stage of medication treatment, from diagnosis to maintenance to medication discontinuation.
Overall findings indicate that evidence-informed strategies for outpatient treatment of pediatric maladaptive aggression, guided by systematically derived expert opinions, are attainable. In light of the gap between the research literature and clinical practice, expert consensus opinion supports specific practices for optimal outpatient management in children and adolescents with severe and persistent behavioral difficulties.
对具有临床显著攻击行为的儿童和青少年进行精神科治疗很常见,且通常涉及使用抗精神病药物。尽管关于儿童攻击行为的最佳诊断、心理社会和药物治疗方法的证据有限,但越来越多的儿科医生开始启动或管理此类治疗。
本研究的目的是收集临床医生和研究人员关于适应不良攻击行为治疗的专业知识,使用专家共识调查方法来帮助制定儿科医生和精神科医生关于青少年适应不良攻击行为门诊治疗(T-MAY)的指南。
46名在儿童攻击行为治疗方面有超过10年临床和/或研究经验的专家(精神科医生、儿科医生和研究人员)完成了一项包含27个项目(超过400种治疗选择)的关于最佳诊断、心理社会和药物治疗的调查。使用描述性统计和置信区间对数据进行分析。
专家共识方法明确区分了适应不良攻击行为的最佳与非最佳治疗策略。与当前的实践趋势相反,结果表明,专家支持在从诊断到维持再到停药的药物治疗的每个阶段,在使用药物治疗适应不良攻击行为之前先使用心理社会干预以及家长教育和培训。
总体研究结果表明,以系统得出的专家意见为指导的、基于证据的儿童适应不良攻击行为门诊治疗策略是可以实现的。鉴于研究文献与临床实践之间的差距,专家共识意见支持对有严重和持续性行为困难的儿童和青少年进行最佳门诊管理的具体做法。