Baeza Immaculada, Correll Christoph U, Saito Ema, Amanbekova Dinara, Ramani Meena, Kapoor Sandeep, Chekuri Raja, De Hert Marc, Carbon Maren
Child and Adolescent Psychiatry and Psychology Department, CIBERSAM IDIBAPS, Hospital Clinic i Universitari, Barcelona, Spain.
J Child Adolesc Psychopharmacol. 2013 May;23(4):271-81. doi: 10.1089/cap.2012.0116. Epub 2013 May 6.
Inpatient aggression is a serious challenge in pediatric psychiatry.
A chart review study in adolescent psychiatric inpatients consecutively admitted over 24 months was conducted, to describe aggressive events requiring an intervention (AERI) and to characterize their management. AERIs were identified based on specific institutional event forms and/or documentation of as-needed (STAT/PRN) medication administration for aggression, both recorded by nursing staff.
Among 408 adolescent inpatients (age: 15.2±1.6 years, 43.9% male), 1349 AERIs were recorded, with ≥1 AERI occurring in 28.4% (n=116; AERI+). However, the frequency of AERIs was highly skewed (median 4, range: 1-258). In a logistical regression model, the primary diagnosis at discharge of disruptive behavior disorders and bipolar disorders, history of previous inpatient treatment, length of hospitalization, and absence of a specific precipitant prior to admission were significantly associated with AERIs (R(2)=0.32; p<0.0001). The first line treatment of patients with AERIs (AERI+) was pharmacological in nature (95.6%). Seclusion or restraint (SRU) was used at least once in 59.4% of the AERI+ subgroup (i.e., in 16.9% of all patients; median within-group SRU frequency: 3). Treatment and discharge characteristics indicated a poorer prognosis in the AERI+ (discharge to residential care AERI+: 22.8%, AERI-: 5.6%, p<0.001) and a greater need for psychotropic polypharmacy (median number of psychotropic medications AERI+: 2; AERI-: 1, p<0.001).
Despite high rates of pharmacological interventions, SRU continue to be used in adolescent inpatient care. As both of these approaches lack a clear evidence base, and as adolescents with clinically significant inpatient aggression have increased illness acuity/severity and service needs, structured research into the most appropriate inpatient aggression management is sorely needed.
住院患者攻击行为是儿童精神病学中的一项严峻挑战。
对连续24个月收治的青少年精神科住院患者进行一项病历回顾研究,以描述需要干预的攻击事件(AERI)并对其管理情况进行特征分析。AERI根据特定的机构事件表格和/或护理人员记录的针对攻击行为的按需(STAT/PRN)用药记录来确定。
在408名青少年住院患者(年龄:15.2±1.6岁,43.9%为男性)中,记录到1349起AERI,28.4%(n = 116;AERI+)的患者发生了≥1起AERI。然而,AERI的发生频率高度不均衡(中位数为4,范围:1 - 258)。在逻辑回归模型中,出院时的破坏性行为障碍和双相情感障碍的主要诊断、既往住院治疗史、住院时间以及入院前无特定诱发因素与AERI显著相关(R(2)=0.32;p<0.0001)。AERI患者(AERI+)的一线治疗本质上是药物治疗(95.6%)。59.4%的AERI+亚组患者至少使用过一次隔离或约束(SRU)(即占所有患者的16.9%;组内SRU频率中位数:3)。治疗和出院特征表明,AERI+患者的预后较差(转至寄宿护理机构的比例:AERI+为22.8%,AERI-为5.6%,p<0.001),且对精神药物联合治疗的需求更大(精神药物中位数数量:AERI+为2;AERI-为1,p<0.001)。
尽管药物干预率很高,但SRU仍在青少年住院护理中使用。由于这两种方法都缺乏明确的证据基础,而且具有临床显著住院攻击行为的青少年疾病严重程度和服务需求增加,因此迫切需要对最适当的住院攻击行为管理进行结构化研究。