蒙古沙鼠（长爪沙鼠）对钩端螺旋体的易感性及疫苗接种的保护作用。
Susceptibility of Mongolian gerbils (Meriones unguiculatus) to leptospires and the protective effect of vaccination.
作者信息
Yukawa M, Mochizuki K, Imamura S
机构信息
Laboratory of Biomedical Science, College of Agriculture and Veterinary Medicine, Nihon University, Fujisawa, Japan.
出版信息
Vet Microbiol. 1990 Jul;24(1):63-71. doi: 10.1016/0378-1135(90)90051-v.
Mongolian gerbils, Meriones unguiculatus, were shown to be highly susceptible to Leptospira interrogans serovars such as icterohaemorrhagiae, copenhageni, canicola, autumnalis, javanica, pyrogenes and hebdomadis as compared to guinea pigs and hamsters. Mortality with signs of haemorrhage and jaundice was recorded in all experimental rodents after intraperitoneal inoculation with all strains of the serovars indicated. However, Mongolian gerbils were comparatively susceptible to strains which were of low virulence to guinea pigs and hamsters. Use of leptospiral vaccination proved effective in protecting the animals against inoculum challenges. The Mongolian gerbil is a species that may be selectively and preferentially useful for assays on the protective effects of leptospiral vaccination.
与豚鼠和仓鼠相比，长爪沙鼠（Meriones unguiculatus）被证明对问号钩端螺旋体血清型如出血性黄疸型、哥本哈根型、犬型、秋季热型、爪哇型、热解型和七日热型高度易感。在用所示血清型的所有菌株进行腹腔接种后，在所有实验啮齿动物中均记录到有出血和黄疸迹象的死亡情况。然而，长爪沙鼠对豚鼠和仓鼠毒力较低的菌株相对易感。事实证明，使用钩端螺旋体疫苗接种可有效保护动物免受接种物的攻击。长爪沙鼠是一种可能对钩端螺旋体疫苗接种的保护作用测定有选择性且优先有用的物种。
Zotero 插件