Trang L E, Lövgren O, Roch-Norlund A E, Horn R S, Walaas O
Scand J Rheumatol. 1979;8(2):91-6. doi: 10.3109/03009747909105343.
Levels of cyclic adenosine 3',5'-monophosphate (cAMP) and cyclic guanosine 3',5'-monophosphate (cGMP) have been investigated in joint fluid in inflammatory arthropathies. A disturbed balance between cAMP and cGMP due to a depressed level of cAMP was found in rheumatoid arthritis (RA) and Reiter's syndrome, in comparison with patients with osteoarthritis. No correlation could be demonstrated between the absolute levels of cAMP or cGMP and the degree of local inflammatory activity, white cell count, or lysosomal enzyme activity in the joint fluid. Intra-articular injection of epinephrine showed just as good an effect on local pain as betamethasone (Cellestona), but the steriod reduced the swelling more effectively. An increase in intracellular levels of cAMP at 20 min was observed following injection of epinephrine with a slight change in cGMP. Intra-articular injection of dibutyryl-cAMP (db-cAMP) produced a marked easing of local pain and swelling in each of the 4 patients so treated. It is concluded that stimulation of the beta-adrenergic system or injection with db-cAMP may be beneficial in rheumatoid inflammation.
在炎症性关节病的关节液中，对环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的水平进行了研究。与骨关节炎患者相比，在类风湿关节炎（RA）和赖特综合征中发现，由于cAMP水平降低，cAMP和cGMP之间的平衡受到干扰。关节液中cAMP或cGMP的绝对水平与局部炎症活动程度、白细胞计数或溶酶体酶活性之间未显示出相关性。关节内注射肾上腺素对局部疼痛的效果与倍他米松（Celestona）一样好，但类固醇更有效地减轻了肿胀。注射肾上腺素后20分钟，观察到细胞内cAMP水平升高，cGMP略有变化。关节内注射二丁酰环磷腺苷（db-cAMP）使接受治疗的4例患者中的每例局部疼痛和肿胀明显减轻。得出的结论是，刺激β-肾上腺素能系统或注射db-cAMP可能对类风湿炎症有益。
