Trang L E, Lövgren O, Horn R, Walaas O, Mjös O
Agents Actions. 1980 Dec;10(6):566-9. doi: 10.1007/BF02024168.
Cyclic 3',5'-adenosine monophosphate (cAMP) and cyclic 3',5' guanosine monophosphate (cGMP) may influence important regulatory mechanisms in the rheumatoid inflammatory process. It has been claimed that fasting improves the condition of the patient with rheumatoid arthritis (RA). The present study was designed to measure cAMP in plasma and urine cGMP in urine in medically untreated RA patients. 12 female patients were investigated in a cross-over study during a control and a fasting period. They received no other drugs than analgesics during these periods. Levels of plasma and urinary cAMP found during the control period were somewhat lower than previously reported. However, the ratio cAMP/cGMP in urine was 10 to 1 which is reported to be normal. Clinical and laboratory variables of inflammatory activity were significantly improved during the 7-day fasting period. The ratio of cAMP/cGMP in urine was significantly increased on days 2-4 and coincided in time with the maximum of clinical improvement. Cyclic AMP concentrations were lowered both in plasma and urine during fasting. This is in contrast to fasting in normal and obese subjects reported in previous studies.
环3',5'-单磷酸腺苷（cAMP）和环3',5'-单磷酸鸟苷（cGMP）可能影响类风湿性炎症过程中的重要调节机制。有人声称禁食可改善类风湿性关节炎（RA）患者的病情。本研究旨在测量未经药物治疗的RA患者血浆中的cAMP和尿液中的cGMP。在一项交叉研究中，对12名女性患者在对照期和禁食期进行了调查。在这些期间，她们除了服用镇痛药外未服用其他药物。对照期测得的血浆和尿cAMP水平略低于先前报道的水平。然而，尿中cAMP/cGMP的比值为10比1，据报道这是正常的。在7天的禁食期内，炎症活动的临床和实验室变量有显著改善。尿中cAMP/cGMP的比值在第2 - 4天显著增加，且与临床改善的最大值在时间上一致。禁食期间血浆和尿液中的环磷酸腺苷浓度均降低。这与先前研究报道的正常人和肥胖受试者的禁食情况相反。
