Wadskov S, Donde R, Sylvest J
Scand J Rheumatol. 1979;8(3):136-8. doi: 10.3109/03009747909114444.
cAMP was measured in plasma and synovial fluid from 11 patients suffering from rheumatoid arthritis with a specific protein-binding assay. Plasma and synovial fluid values were 17.0 +/- 6.8 pmol/ml and 8.3 +/- 3.7 pmol/ml, range 5-28 pmol/ml and 5-16 pmol/ml, respectively. No correlation could be established between plasma and synovial fluid levels, plasma and disease activity, or synovial fluid and disease activity, as judged by Lansbury's index. It is concluded that it seems unlikely that synovial fluid cAMP is derived solely from plasma and that no simple relation exists between cAMP in plasma and synovial fluid and total disease activity.
采用特异性蛋白结合分析法测定了11例类风湿性关节炎患者血浆和滑液中的环磷腺苷（cAMP）。血浆和滑液中cAMP的值分别为17.0±6.8皮摩尔/毫升和8.3±3.7皮摩尔/毫升，范围分别为5 - 28皮摩尔/毫升和5 - 16皮摩尔/毫升。根据兰斯伯里指数判断，血浆和滑液水平之间、血浆与疾病活动度之间或滑液与疾病活动度之间均未发现相关性。结论是，滑液中的cAMP似乎不太可能仅来源于血浆，而且血浆和滑液中的cAMP与疾病总活动度之间不存在简单的关系。
