Department of Agri-food Protection and Valorisation (DIPROVAL), Faculty of Agriculture, University of Bologna, Reggio Emilia, Italy.
Meat Sci. 2012 Apr;90(4):887-92. doi: 10.1016/j.meatsci.2011.11.025. Epub 2011 Nov 12.
The melanocortin-4 receptor (MC4R) gene codes for a G protein transmembrane receptor playing an important role in energy homeostasis control. In pig a single nucleotide polymorphism c.1426G>A has been identified and associated to average daily gain, feed intake and fatness traits but a lack of agreement on the effects of the gene on carcass traits in different breeds comes out from many studies. In the present study the c.1426G>A polymorphism is analysed in two Italian pig breeds, Large White and Duroc to study the association of the MC4R gene with some carcass traits. The results show that the c.1426G>A polymorphism affects daily gain, feed conversion ratio and ham weight in both breeds, lean cuts in the Italian Duroc and backfat thickness in the Italian Large White. The presence of MC4R mRNA transcript in different porcine tissues was analysed.
黑皮质素 4 受体 (MC4R) 基因编码一种 G 蛋白跨膜受体，在能量平衡控制中发挥重要作用。在猪中，已经鉴定出单核苷酸多态性 c.1426G>A，与平均日增重、采食量和肥胖性状有关，但许多研究表明，该基因对不同品种的胴体性状的影响存在分歧。本研究分析了意大利两个猪品种（大白猪和杜洛克猪）中的 c.1426G>A 多态性，以研究 MC4R 基因与一些胴体性状的关系。结果表明，该多态性影响了两个品种的日增重、饲料转化率和火腿重量，意大利杜洛克猪的瘦肉比例和意大利大白猪的背膘厚度。还分析了不同猪组织中 MC4R mRNA 转录本的存在。
