Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Trends Cogn Sci. 2012 Jan;16(1):61-71. doi: 10.1016/j.tics.2011.12.011. Epub 2011 Dec 21.
Although mood disorders constitute leading causes of disability, until recently little was known about their pathogenesis. The delineation of anatomical networks that support emotional behavior (mainly derived from animal studies) and the development of neuroimaging technologies that allow in vivo characterization of anatomy, physiology, and neurochemistry in human subjects with mood disorders have enabled significant advances towards elucidating the pathophysiology of major depressive disorder (MDD) and bipolar disorder (BD). In this review, we integrate insights from human and animal studies, which collectively suggest that MDD and BD involve dysfunction within an extended network including the medial prefrontal cortex and anatomically-related limbic, striatal, thalamic and basal forebrain structures.
尽管情绪障碍是导致残疾的主要原因之一，但直到最近，人们对其发病机制还知之甚少。支持情绪行为的解剖网络的描绘（主要来自动物研究），以及神经影像学技术的发展，使得人们能够在有情绪障碍的人类受试者中对解剖结构、生理和神经化学进行体内特征描述，这为阐明重性抑郁障碍（MDD）和双相障碍（BD）的病理生理学提供了重要进展。在这篇综述中，我们整合了来自人类和动物研究的见解，这些研究共同表明，MDD 和 BD 涉及包括内侧前额叶皮层和解剖相关的边缘系统、纹状体、丘脑和基底前脑结构在内的扩展网络中的功能障碍。
