Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Exp Physiol. 2012 Apr;97(4):469-73. doi: 10.1113/expphysiol.2011.063362. Epub 2011 Dec 23.
Coughing and swallowing are airway-protective behaviours. The pharyngeal phase of swallowing prevents aspiration of oral material (saliva, food and liquid) by epiglottal movement, laryngeal adduction and clearing of the mouth and pharynx. Coughing is an aspiration-response behaviour that removes material from the airway. Co-ordination of these behaviours is vital to protect the airway from further aspiration-promoting events, such as a swallowing during the inspiratory phase of coughing. The operational characteristics, primary strategies and peripheral inputs that co-ordinate coughing and swallowing are unknown. This lack of knowledge impedes understanding and treatment of deficits in airway protection, such as the co-occurrence of dystussia and dysphagia common in Parkinson's and Alzheimer's diseases, as well as stroke.
咳嗽和吞咽是气道保护行为。吞咽的咽期通过会厌运动、喉内收和清除口腔和咽部来防止口腔物质（唾液、食物和液体）被吸入。咳嗽是一种清除气道内物质的吸入反应行为。协调这些行为对于保护气道免受进一步促进吸入的事件（如咳嗽时的吸气期吞咽）至关重要。协调咳嗽和吞咽的操作特征、主要策略和外周输入尚不清楚。这种知识的缺乏阻碍了对气道保护缺陷的理解和治疗，例如帕金森病和阿尔茨海默病中常见的发音困难和吞咽困难以及中风。
