Pharmacology Program, School of Medicine, ICBM, Faculty of Medicine, Universidad de Chile, Independencia 1027, Santiago 7, Chile.
Inflammation. 2012 Jun;35(3):1132-7. doi: 10.1007/s10753-011-9420-7.
Opioids have been used for long time to management of pain, the coadministration of two opioids may induce synergism. The present study was conducted to determine the antinociceptive interaction between the dual mechanism of action of tramadol compared to the main of fentanyl antinociception in the orofacial formalin which represents a model of persistent cutaneous nociception in the region innervated by the trigeminal nerve. The i.p. administration of tramadol and fentanyl induced a dose-dependent antinociception with an ED(50) of 2.97 ± 0.32 mg/kg for phase I and 1.79 ± 0.30 mg/kg for phase II and 0.062 ± 0.0040 mg/kg in phase I and 0.041 ± 0.0039 mg/kg in phase II, respectively. The coadministration of fentanyl with tramadol induced synergism in both phases of the test with an interaction index of 0.343 and 0.163 for phase I and phase II, respectively. This finding could be explained by the more complex pharmacology of tramadol compared to fentanyl.
阿片类药物长期以来一直被用于疼痛管理，两种阿片类药物的联合使用可能会产生协同作用。本研究旨在确定曲马多的双重作用机制与芬太尼的主要作用机制在口腔福尔马林中的镇痛相互作用，口腔福尔马林代表了三叉神经支配区域持续皮肤痛觉的模型。曲马多和芬太尼的腹腔给药诱导出剂量依赖性镇痛作用，I 相的 ED（50）为 2.97±0.32mg/kg，II 相的 ED（50）为 1.79±0.30mg/kg，I 相的 ED（50）为 0.062±0.0040mg/kg，II 相的 ED（50）为 0.041±0.0039mg/kg。芬太尼与曲马多联合给药在测试的两个阶段均产生协同作用，I 相和 II 相的相互作用指数分别为 0.343 和 0.163。与芬太尼相比，曲马多更复杂的药理学可以解释这一发现。
