Demirkaya Kadriye, Akgün Özlem Martı, Şenel Buğra, Öncel Torun Zeynep, Seyrek Melik, Lacivita Enza, Leopoldo Marcello, Doğrul Ahmet
- Gulhane Medical Academy, Department of Restorative Dentistry and Endodontics, Ankara, Turkey.
- Gulhane Medical Academy, Department of Pediatric Dentistry, Ankara, Turkey.
J Appl Oral Sci. 2016 May-Jun;24(3):218-22. doi: 10.1590/1678-775720150563.
To investigate the antinociceptive effects of pharmacological activation of 5-HT7 receptors on orofacial pain in mice.
Nociception was evaluated by using an orofacial formalin test in male Balb-C mice. Selective 5-HT7 receptor agonists, LP 44 and LP 211 (1, 5, and 10 mg/kg), were given intraperitoneally 30 min prior to a formalin injection. A bolus of 10 µl of 4% subcutaneous formalin was injected into the upper lip of mice and facial grooming behaviors were monitored. The behavioral responses consisted of two distinct periods, the early phase corresponding to acute pain (Phase I: 0-12 min) and the late phase (Phase II: 12-30 min).
LP 44 and LP 211 (1, 5, and 10 mg/kg) produced an analgesic effect with reductions in face rubbing time in both Phase I and Phase II of the formalin test.
Our results suggest that 5-HT7 receptor agonists may be promising analgesic drugs in the treatment of orofacial pain.
研究5-羟色胺7（5-HT7）受体的药理学激活对小鼠口腔面部疼痛的抗伤害感受作用。
采用口腔面部福尔马林试验对雄性Balb-C小鼠的伤害感受进行评估。在福尔马林注射前30分钟腹腔注射选择性5-HT7受体激动剂LP 44和LP 211（1、5和10毫克/千克）。将10微升4%的皮下福尔马林注射到小鼠上唇，并监测面部梳理行为。行为反应包括两个不同阶段，早期阶段对应急性疼痛（第一阶段：0-12分钟）和晚期阶段（第二阶段：12-30分钟）。
LP 44和LP 211（1、5和10毫克/千克）在福尔马林试验的第一阶段和第二阶段均产生镇痛作用，面部摩擦时间减少。
我们的结果表明，5-HT7受体激动剂可能是治疗口腔面部疼痛的有前景的镇痛药。
