Yoon Se-Jung, Park Sungha, Park Chanmi, Chang Woochul, Cho Deok-Kyu, Ko Young-Guk, Choi Donghoon, Kwon Hyuck Moon, Jang Yangsoo, Chung Namsik
Division of Cardiology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
Coron Artery Dis. 2012 Mar;23(2):85-90. doi: 10.1097/MCA.0b013e32834f114e.
In humans, a secreted isoform of (soluble) receptor for advanced glycation end-products (sRAGE) may act as a decoy receptor of advanced glycation end-product. The level of sRAGE may reflect the activity of cell surface receptor for advanced glycation end-product. But there has been no study that has demonstrated the association of sRAGE with central aortic stiffness. Here, we studied the relation of plasma sRAGE level and arterial pulse wave velocity in hypertensive patients.
A total of 415 patients were enrolled (men; 57.6%, mean age; 53.2±10.8 years), with 25.8% (n=107) of these being diabetic. All patients underwent pulse wave velocity (PWV) and blood sampling of sRAGE, high-sensitive C-reactive protein, and other serologic markers.
The log-transformed sRAGE was significantly correlated with the marker of central aortic stiffness heart to femoral PWV (hfPWV; r=0.165, P=0.001). It also showed a significant correlation with hfPWV in patients with diabetes (r=0.301, P=0.002), but not in patients without diabetes (r=0.115, P=0.055). By multiple linear regression analysis, the log-transformed sRAGE was independently correlated with hfPWV (β=0.13, P=0.004) when controlled for other variables.
This study has demonstrated, for the first time, that serum sRAGE level was independently correlated with a marker of central aortic stiffness. This result suggests the potential role of RAGE in the pathogenesis of aortic stiffness.
在人类中，晚期糖基化终产物（AGE）的一种分泌型（可溶性）受体（sRAGE）可能作为AGE的诱饵受体。sRAGE的水平可能反映晚期糖基化终产物细胞表面受体的活性。但尚无研究证实sRAGE与中心主动脉僵硬度之间的关联。在此，我们研究了高血压患者血浆sRAGE水平与动脉脉搏波速度之间的关系。
共纳入415例患者（男性占57.6%，平均年龄53.2±10.8岁），其中25.8%（n = 107）为糖尿病患者。所有患者均接受脉搏波速度（PWV）测量以及sRAGE、高敏C反应蛋白和其他血清学标志物的血液采样。
经对数转换的sRAGE与中心主动脉僵硬度标志物心脏至股动脉脉搏波速度（hfPWV）显著相关（r = 0.165，P = 0.001）。在糖尿病患者中，它与hfPWV也显著相关（r = 0.301，P = 0.002），但在非糖尿病患者中无显著相关性（r = 0.115，P = 0.055）。通过多元线性回归分析，在控制其他变量时，经对数转换的sRAGE与hfPWV独立相关（β = 0.13，P = 0.004）。
本研究首次证明血清sRAGE水平与中心主动脉僵硬度标志物独立相关。这一结果提示RAGE在主动脉僵硬度发病机制中的潜在作用。
