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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bakke J E, Feil V J, Mulford D J

Biosciences Research Laboratory, US Department of Agriculture, Fargo, ND 58105.

Xenobiotica. 1990 Jun;20(6):601-5. doi: 10.3109/00498259009046875.

Biliary metabolites from rats dosed with pentachlorothioanisole (PCTA) were characterized by fast atom bombardment mass spectrometry and electron impact mass spectrometry. 2. Most of the biliary metabolites from PCTA were mercapturic acid pathway metabolites of methylsulphinyltetrachlorobenzene (51% of the dose); the remaining characterized biliary metabolites (20%) were mainly methylsulphinyltetrachlorothiophenols excreted as unknown conjugates. 3. Pathways are proposed for the intermediary metabolism of PCTA to bis-(methylthio)tetrachlorobenzene (bis-MTTCB) involving glutathione conjugation, biliary excretion, intestinal metabolism, and enterohepatic circulation.

采用快原子轰击质谱法和电子轰击质谱法对用五氯硫代苯甲醚（PCTA）给药的大鼠胆汁代谢产物进行了表征。2. PCTA的大部分胆汁代谢产物是甲基亚砜基四氯苯的硫醚氨酸途径代谢产物（占剂量的51%）；其余已鉴定的胆汁代谢产物（20%）主要是以未知共轭物形式排泄的甲基亚砜基四氯硫酚。3. 提出了PCTA中间代谢为双（甲硫基）四氯苯（双-MTTCB）的途径，该途径涉及谷胱甘肽共轭、胆汁排泄、肠道代谢和肠肝循环。

Bakke J E, Feil V J, Mulford D J

Biosciences Research Laboratory, US Department of Agriculture, Fargo, ND 58105.

Xenobiotica. 1990 Jun;20(6):601-5. doi: 10.3109/00498259009046875.

Biliary metabolites from rats dosed with pentachlorothioanisole (PCTA) were characterized by fast atom bombardment mass spectrometry and electron impact mass spectrometry. 2. Most of the biliary metabolites from PCTA were mercapturic acid pathway metabolites of methylsulphinyltetrachlorobenzene (51% of the dose); the remaining characterized biliary metabolites (20%) were mainly methylsulphinyltetrachlorothiophenols excreted as unknown conjugates. 3. Pathways are proposed for the intermediary metabolism of PCTA to bis-(methylthio)tetrachlorobenzene (bis-MTTCB) involving glutathione conjugation, biliary excretion, intestinal metabolism, and enterohepatic circulation.

采用快原子轰击质谱法和电子轰击质谱法对用五氯硫代苯甲醚（PCTA）给药的大鼠胆汁代谢产物进行了表征。2. PCTA的大部分胆汁代谢产物是甲基亚砜基四氯苯的硫醚氨酸途径代谢产物（占剂量的51%）；其余已鉴定的胆汁代谢产物（20%）主要是以未知共轭物形式排泄的甲基亚砜基四氯硫酚。3. 提出了PCTA中间代谢为双（甲硫基）四氯苯（双-MTTCB）的途径，该途径涉及谷胱甘肽共轭、胆汁排泄、肠道代谢和肠肝循环。