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大鼠体内谷胱甘肽-S-转移酶介导的五氯硫代苯甲醚代谢中的甲硫基置换与周转

Glutathione-S-transferase-mediated methylthio displacement and turnover in the metabolism of pentachlorothioanisole by rats.

作者信息

Mulford D J, Bakke J E, Feil V J

机构信息

Department of Biochemistry, North Dakota State University, Fargo 58105.

出版信息

Xenobiotica. 1991 May;21(5):597-603. doi: 10.3109/00498259109039499.

DOI:10.3109/00498259109039499
PMID:1949892
Abstract
  1. The metabolism of pentachlorothioanisole to bis-(methylthio)tetrachlorobenzene was shown to involve turnover of about 50% of the original methylthio group. 2. Metabolites of the displaced methylthio group were methanesulphinic acid and sulphate in the urine, carbon dioxide in the expired air, and unidentified sulphur-containing compounds in the bile.
摘要
  1. 五氯硫代苯甲醚代谢生成双（甲硫基）四氯苯的过程表明，约50%的原始甲硫基发生了周转。2. 被取代甲硫基的代谢产物在尿液中为甲亚磺酸和硫酸盐，在呼出气体中为二氧化碳，在胆汁中为未鉴定的含硫化合物。

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