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谷胱甘肽介导的甲硫基周转以及大鼠对五氯硫代苯甲醚代谢的性别差异。

Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat.

作者信息

Bakke J E, Mulford D J, Huwe J K, Feil V J, Davison K L

机构信息

US Department of Agriculture, Biosciences Research Laboratory, Fargo, ND 58105.

出版信息

Xenobiotica. 1993 Aug;23(8):949-60. doi: 10.3109/00498259309059421.

DOI:10.3109/00498259309059421
PMID:8284949
Abstract
  1. Sex differences observed in the metabolism of pentachlorothioanisole in rat were due to: (1) greater excretion in urine by females, and greater biliary excretion by males; (2) formation of pentachlorophenyl mercapturic acid pathway metabolites by females; and (3) redox-cycling between methylthio and methylsulphoxyl oxidation congeners in intermediary metabolites by females. 2. Three methylthio-turnover processes are proposed in the intermediary metabolism of pentachlorothioanisole.
摘要
  1. 在大鼠中观察到的五氯硫代苯甲醚代谢的性别差异归因于：（1）雌性大鼠尿液排泄量更大，雄性大鼠胆汁排泄量更大；（2）雌性大鼠形成五氯苯基硫醚氨酸途径代谢物；（3）雌性大鼠中间代谢物中的甲硫基和甲磺酰氧化同系物之间的氧化还原循环。2. 提出了五氯硫代苯甲醚中间代谢中的三种甲硫基周转过程。

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