E2F与微小RNA对血管生成的调控
E2F and microRNA regulation of angiogenesis.
作者信息
Biyashev Dauren, Qin Gangjian
机构信息
Feinberg Cardiovascular Research Institute, Department of Medicine, Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
出版信息
Am J Cardiovasc Dis. 2011;1(2):110-118.
Abstract
E2F family of transcription factors are best known for regulating genes involved in cell cycle control, cell proliferation, tumorigenesis, and apoptosis. Recent evidences have revealed their critical involvement in modulating cellular response to hypoxia and ischemia in a variety of physiological and pathological processes. Of particular interest are findings that E2Fs act as both regulators and targets of microRNAs that govern hypoxic/ischemic angiogenesis. This review focuses on the crosstalk between E2Fs and microRNAs that have been shown to participate in the regulation of angiogenesis, hypoxia response and ischemic disease.
摘要
E2F转录因子家族最为人所知的是其对参与细胞周期调控、细胞增殖、肿瘤发生和细胞凋亡的基因的调控作用。最近的证据表明，它们在多种生理和病理过程中对调节细胞对缺氧和缺血的反应起着关键作用。特别值得关注的是，有研究发现E2F既是调控缺氧/缺血性血管生成的微小RNA的调节因子，也是其作用靶点。本综述重点关注E2F与微小RNA之间的相互作用，这些相互作用已被证明参与血管生成、缺氧反应和缺血性疾病的调控。
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