Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, QLD 4072, Australia.
Nanoscale. 2012 Feb 7;4(3):970-5. doi: 10.1039/c2nr11691j. Epub 2011 Dec 23.
In this proof-of-concept study, an agricultural biocide (imidacloprid) was effectively loaded into the mesoporous silica nanoparticles (MSNs) with different pore sizes, morphologies and mesoporous structures for termite control. This resulted in nanoparticles with a large surface area, tunable pore diameter and small particle size, which are ideal carriers for adsorption and controlled release of imidacloprid. The effect of pore size, surface area and mesoporous structure on uptake and release of imidacloprid was systematically studied. It was found that the adsorption amount and release profile of imidacloprid were dependent on the type of mesoporous structure and surface area of particles. Specifically, MCM-48 type mesoporous silica nanoparticles with a three dimensional (3D) open network structure and high surface area displayed the highest adsorption capacity compared to other types of silica nanoparticles. Release of imidacloprid from these nanoparticles was found to be controlled over 48 hours. Finally, in vivo laboratory testing on termite control proved the efficacy of these nanoparticles as delivery carriers for biopesticides. We believe that the present study will contribute to the design of more effective controlled and targeted delivery for other biomolecules.
在这项概念验证研究中，我们将农用杀生物剂（吡虫啉）有效地负载到具有不同孔径、形态和介孔结构的介孔硅纳米粒子（MSNs）中，以实现白蚁防治。这导致了具有大表面积、可调孔径和小粒径的纳米粒子的形成，这些粒子是吸附和控制吡虫啉释放的理想载体。我们系统地研究了孔径、表面积和介孔结构对吡虫啉的摄取和释放的影响。结果发现，吡虫啉的吸附量和释放曲线依赖于介孔结构的类型和粒子的表面积。具体而言，与其他类型的硅纳米粒子相比，具有三维（3D）开放网络结构和高表面积的 MCM-48 型介孔硅纳米粒子显示出最高的吸附能力。这些纳米粒子对吡虫啉的释放被发现可以控制在 48 小时以上。最后，对白蚁防治的体内实验室测试证明了这些纳米粒子作为生物农药的递送载体的功效。我们相信，本研究将有助于设计更有效的控制和靶向传递其他生物分子。
