Shoaib Ali, Waqas Muhammad, Elabasy Asem, Cheng Xinlai, Zhang Qianqian, Shi Zuhua
Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Ministry of Agriculture, Institute of Insect Sciences, Zhejiang University 866 Yuhangtang Road Hangzhou 310058 China
Department of Pesticides, Plant Protection Research Institute, Agricultural Research Centre Cairo Egypt.
RSC Adv. 2018 Apr 26;8(28):15687-15697. doi: 10.1039/c8ra01913d. eCollection 2018 Apr 23.
Colloidal delivery systems have been widely used as carriers for controlled delivery of pesticides to improve the efficacy and photostability of natural and semi-synthetic pesticides. In this study, we have synthesized emamectin benzoate nanoformulations (EB + NFs) depending on polymeric nanocapsules (PNC) and two types of the nanosilica, mesoporous nanosilica (MCM-48) and silicon dioxide nanoparticles (SNPs) as carriers for the emamectin benzoate (EB). The fabricated nanoformulations were characterized by using X-ray diffraction analysis, Fourier transform infrared spectroscopy, particle size, zeta potential, morphology, absolute recovery (AR), entrapment efficiency (EE), UV stability and release kinetics. The obtained results showed that the carriers had a remarkable loading ability for EB and improved the EB photostability. The EE% of nanoformulations were 92.84%, 87.45% and 71.19% for emamectin benzoate polymeric nanocapsules (EB + PNC), emamectin benzoate SNPs (EB + SNPs) and emamectin benzoate MCM-48 (EB + MCM-48) respectively. The insecticidal activity of EB + NFs against showed that the EB + SNPs was more effective than other EB + NFs and EB alone. The LC values were 0.18, 4.03, 8.49 and 11.06 mg L for EB + SNPs, EB + MCM-48, EB + PNC and EB respectively. The obtained results suggest the colloidal delivery systems that used in this study could improve the efficacy and photostability for EB, and they are able to overcome the disadvantage of the natural and semi-synthetic pesticides such as environmental sensitivity and to increase the efficacy of pesticides, which eventually leads to reduce the dosage of pesticides needed, reducing the number of applications required in comparison to conventional formulations.
胶体递送系统已被广泛用作农药控释载体，以提高天然和半合成农药的功效和光稳定性。在本研究中，我们以聚合物纳米胶囊（PNC）以及两种类型的纳米二氧化硅——介孔纳米二氧化硅（MCM - 48）和二氧化硅纳米颗粒（SNP）作为甲氨基阿维菌素苯甲酸盐（EB）的载体，合成了甲氨基阿维菌素苯甲酸盐纳米制剂（EB + NFs）。通过X射线衍射分析、傅里叶变换红外光谱、粒径、zeta电位、形态、绝对回收率（AR）、包封率（EE）、紫外稳定性和释放动力学对制备的纳米制剂进行了表征。所得结果表明，这些载体对EB具有显著的负载能力，并提高了EB的光稳定性。甲氨基阿维菌素苯甲酸盐聚合物纳米胶囊（EB + PNC）、甲氨基阿维菌素苯甲酸盐SNP（EB + SNPs）和甲氨基阿维菌素苯甲酸盐MCM - 48（EB + MCM - 48）的纳米制剂的包封率分别为92.84%、87.45%和71.19%。EB + NFs对[此处原文缺失具体对象]的杀虫活性表明，EB + SNPs比其他EB + NFs以及单独的EB更有效。EB + SNPs、EB + MCM - 48、EB + PNC和EB的LC值分别为0.18、4.03、8.49和11.06 mg/L。所得结果表明，本研究中使用的胶体递送系统可以提高EB的功效和光稳定性，并且能够克服天然和半合成农药的缺点，如对环境敏感，同时提高农药的功效，最终减少所需农药的剂量，与传统制剂相比减少所需的施用次数。
