Li D B, Wei X, Jiang L H, Wang Y, Xu F
Department of Urology, First Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China.
Genet Mol Res. 2010 Aug 17;9(3):1599-605. doi: 10.4238/vol9-3gmr882.
Although there have been many studies investigating a possible association between p53 codon 72 polymorphism and risk of bladder cancer, the results have been inconsistent. We conducted a meta-analysis of six epidemiological studies, which included 597 bladder cancer cases and 731 controls. Patients with bladder cancer had a significantly lower frequency of Pro/Arg [odds ratio (OR) = 0.80, 95% confidence interval (CI) = 0.64-0.99], when compared to controls. Stratifying for race, we found that among Caucasians, patients with bladder cancer had a significantly higher frequency of Arg/Arg (OR = 1.64, 95%CI = 1.18-2.28) and a lower frequency of Pro/Arg (OR = 0.62, 95%CI = 0.44-0.86), compared to controls. Stratifying various studies by the stage of bladder cancer, we found that invasive bladder cancers had a significantly lower frequency of Arg/Arg (OR = 0.58, 95%CI = 0.36-0.93) and a higher frequency of Pro/Arg (OR = 0.62, 95%CI = 0.44-0.86) than did non-invasive bladder cancers. No significant association was found between this genotype and human papilloma virus. Based on our meta-analysis, we suggest that p53 codon 72 polymorphism is associated with bladder cancer and that genotypic distribution of this polymorphism varies with the stage of bladder cancer.
尽管已有许多研究探讨p53基因第72位密码子多态性与膀胱癌风险之间的可能关联，但其结果并不一致。我们对六项流行病学研究进行了荟萃分析，这些研究包括597例膀胱癌病例和731例对照。与对照组相比，膀胱癌患者中Pro/Arg的频率显著更低[比值比(OR)=0.80，95%置信区间(CI)=0.64 - 0.99]。按种族分层后，我们发现，在白种人中，与对照组相比，膀胱癌患者中Arg/Arg的频率显著更高(OR = 1.64，95%CI = 1.18 - 2.28)，而Pro/Arg的频率更低(OR = 0.62，95%CI = 0.44 - 0.86)。按膀胱癌分期对各项研究进行分层后，我们发现，浸润性膀胱癌中Arg/Arg的频率显著低于非浸润性膀胱癌(OR = 0.58，95%CI = 0.36 - 0.93)，而Pro/Arg的频率则更高(OR = 0.62，95%CI = 0.44 - 0.86)。未发现该基因型与人类乳头瘤病毒之间存在显著关联。基于我们的荟萃分析，我们认为p53基因第72位密码子多态性与膀胱癌有关，且该多态性的基因型分布随膀胱癌分期而变化。
