College of Biological Science and Biotechnology, Shenyang Agricultural University, Shenyang 110866, PR China.
Oncol Rep. 2012 Apr;27(4):903-10. doi: 10.3892/or.2011.1611. Epub 2011 Dec 23.
miRNAs are small, endogenous, non-coding RNAs that negatively regulate protein-coding mRNAs at the post-transcriptional level. It is estimated that in humans thousands of miRNAs are expressed and more than 700 miRNAs have been described to date. About 50% of annotated human miRNAs are detected in regions of fragile sites, which are associated with cancer. The available evidence has shown that miRNAs widely participate in the development or progression of many types of cancers, including breast cancer. The role of miRNAs in breast cancer has been widely investigated; here, we will focus on what is known about the working mechanism of miRNAs in different stages of breast cancer development.
miRNAs 是小的、内源性的、非编码 RNA，在转录后水平负调控蛋白质编码 mRNA。据估计，在人类中表达了数千种 miRNAs，迄今为止已经描述了超过 700 种 miRNAs。大约 50%注释的人类 miRNAs 存在于脆性位点区域，这些区域与癌症相关。现有证据表明，miRNAs 广泛参与多种类型癌症的发生或进展，包括乳腺癌。miRNAs 在乳腺癌中的作用已被广泛研究；在这里，我们将重点介绍已知的 miRNAs 在乳腺癌发展的不同阶段的工作机制。
