PIVET Medical Centre, 166-168 Cambridge Street, Leederville, WA 6007, Australia.
Reprod Biol. 2011 Dec;11 Suppl 3:31-42.
This invited presentation is intended to cover clinical developments in the evolution of assisted reproductive technology (ART), a process which was attempted during the 1940's and 50's and culminated in the first fruition in 1978. The first in vitro fertilisation (IVF) child ensued following the partnership by a scientist with a focussed ambition (Nobel laureate Robert Edwards) joining with the gynaecologist who introduced laparoscopy to Britain in the late 60's (Patrick Steptoe). My journey commenced in 1976 as a clinician who became immersed in the embryological and endocrinological science, whence most progress in ART emanates, and continued into a medical directorship position from which this personal view is documented. Several clinical advances have been important developments in the understanding and management of sub-fertile patients. However evolution of the various laboratory sciences has been the major key essential to meeting both the immediate as well as the long-term needs for human reproduction. The future requires a much better understanding and control over gametogenesis and a laboratory process which much more closely duplicates intrinsic reproductive physiology, avoiding gamete and embryo exposure to the atmosphere.This invited presentation is intended to cover clinical developments in the evolution of assisted reproductive technology (ART), a process which was attempted during the 1940's and 50's and culminated in the first fruition in 1978. The first in vitro fertilisation (IVF) child ensued following the partnership by a scientist with a focussed ambition (Nobel laureate Robert Edwards) joining with the gynaecologist who introduced laparoscopy to Britain in the late 60's (Patrick Steptoe). My journey commenced in 1976 as a clinician who became immersed in the embryological and endocrinological science, whence most progress in ART emanates, and continued into a medical directorship position from which this personal view is documented. Several clinical advances have been important developments in the understanding and management of sub-fertile patients. However evolution of the various laboratory sciences has been the major key essential to meeting both the immediate as well as the long-term needs for human reproduction. The future requires a much better understanding and control over gametogenesis and a laboratory process which much more closely duplicates intrinsic reproductive physiology, avoiding gamete and embryo exposure to the atmosphere.
本特邀演讲旨在涵盖辅助生殖技术 (ART) 发展过程中的临床进展，这一过程始于 20 世纪 40 年代和 50 年代，并在 1978 年首次取得成果。第一位体外受精 (IVF) 婴儿诞生于一位具有明确目标的科学家（诺贝尔奖得主罗伯特·爱德华兹）与 60 年代末将腹腔镜技术引入英国的妇科医生（帕特里克·斯特普托）合作之后。我的旅程始于 1976 年，当时我是一名临床医生，全身心投入到胚胎学和内分泌学科学中，而这也是 ART 取得大多数进展的领域，并继续担任医学主任职务，我将从这个职位的角度记录个人观点。几项临床进展是理解和管理不孕患者的重要发展。然而，各种实验室科学的发展一直是满足人类生殖即时和长期需求的主要关键。未来需要更好地理解和控制配子发生以及更紧密地复制内在生殖生理学的实验室过程，避免配子和胚胎暴露在大气中。
