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[维生素D与双膦酸盐相关颌骨坏死（BRONJ）]

[Vitamin D and bisphosphonate-related osteonecrosis of the jaw (BRONJ) ].

作者信息

Hokugo Akishige

机构信息

Weintraub Center for Reconstructive Biotechnology, UCLA School of Dentistry.

出版信息

Clin Calcium. 2012 Jan;22(1):83-90.

PMID:22201103
Abstract

Bisphosphonate have been widely used for the treatment of osteoporosis and malignant hypercalcemia or bone metastasis of solid cancers. Recently bisphosphonate-related osteonecrosis of the jaw (BRONJ) has been reported. However the pathogenesis of BRONJ has been unclear. This article reviews the various hypotheses of the pathogenesis of BRONJ including our hypothesis for its pathogenesis.

摘要

双膦酸盐已被广泛用于治疗骨质疏松症、恶性高钙血症或实体癌的骨转移。最近，双膦酸盐相关的颌骨坏死（BRONJ）已有报道。然而，BRONJ的发病机制尚不清楚。本文综述了BRONJ发病机制的各种假说，包括我们对其发病机制的假说。

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