Takedachi Masahide, Murakami Shinya
Department of Periodontology, Osaka University Graduate School of Dentistry, Japan.
Clin Calcium. 2012 Jan;22(1):99-104.
Periodontal regenerative therapy is required to regain the tooth function and oral health for patients with periodontal diseases. We reported that topical application of basic fibroblast growth factor (FGF-2) into alveolar bone defects stimulated significant periodontal regeneration in periodontitis patients. On the other hand, subcutaneous administration of Teriparatide, a drug composed of the first 34 amino acids of parathyroid hormone that has anabolic effects for osteoporosis, has been reported to induce periodontal regeneration in the clinical trial. Both of the therapies have been expected to be the periodontal regeneration therapy of the next generation. In this review, we introduce the present status of these new periodontal regenerative therapies.
牙周再生治疗对于牙周疾病患者恢复牙齿功能和口腔健康是必要的。我们报道过，将碱性成纤维细胞生长因子（FGF - 2）局部应用于牙槽骨缺损处可刺激牙周炎患者实现显著的牙周再生。另一方面，在临床试验中，已报道皮下注射特立帕肽（一种由甲状旁腺激素的前34个氨基酸组成、对骨质疏松症有合成代谢作用的药物）可诱导牙周再生。这两种治疗方法都有望成为下一代牙周再生治疗方法。在这篇综述中，我们介绍这些新型牙周再生治疗方法的现状。
