Brattmo Marianne, Tideholm Bo, Carlborg Bjorn
Department of Otorhinolaryngology, Lund University, Malmö, Sweden.
Acta Otolaryngol. 2012 Mar;132(3):255-60. doi: 10.3109/00016489.2011.637175. Epub 2011 Dec 27.
In this physiological study subjects with Meniere's disease (MD) had high resistance to opening of the eustachian tube (ET) in three of four provocation tests. These subjects can be exposed to pressure deviations in the middle ear (ME) above their equalizing capacity. Transmission of the pressure deviations to the inner ear fluids and influence of the symptoms of MD are feasible.
The aim of the study was to reveal potential inadequacy in the ET equilibration capacity and deviations in ME pressure in patients with MD.
Direct ME pressure measurements were made during provocation tests of the ET, and continuously during the daytime and night-time in 21 patients with unilateral, definite and active MD. Twenty subjects with healthy ears (HEs) were used for comparison.
In all, 15/21 subjects could not equilibrate an induced positive and/or negative pressure in the ME by deglutition; 9/21 subjects were not able to perform Valsalva's manoeuvre. All the controls could effectively perform these manoeuvres. However, the continuous measurements showed a similar pressure pattern in patients with MD and the controls, i.e. a slightly negative mean ME pressure during the daytime and positive pressure during sleep.
在这项生理学研究中，梅尼埃病（MD）患者在四项激发试验中的四项中有三项咽鼓管（ET）开放阻力较高。这些患者中耳（ME）压力偏差可能超过其平衡能力。压力偏差向内耳液体的传导以及对MD症状的影响是可能的。
本研究旨在揭示MD患者ET平衡能力的潜在不足以及ME压力偏差。
对21例单侧、明确且处于活动期的MD患者在ET激发试验期间以及白天和夜间连续进行ME压力直接测量。选取20例听力正常的受试者（HEs）作为对照。
总体而言，21例受试者中有15例无法通过吞咽平衡ME中诱导的正压和/或负压；21例受试者中有9例无法完成瓦尔萨尔瓦动作。所有对照组均能有效完成这些动作。然而，连续测量显示MD患者和对照组的压力模式相似，即白天平均ME压力略为负压，睡眠期间为正压。
