Chin Eric K, Sedeek Ragui W, Li Yueju, Beckett Laurel, Redenbo Ellen, Chandra Karishma, Park Susanna S
Department of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, California 95817, USA.
Ophthalmic Surg Lasers Imaging. 2012 Mar-Apr;43(2):97-108. doi: 10.3928/15428877-20111222-02. Epub 2012 Jan 3.
To study the effect of image resolution, eye tracking, and image registration on central macular thickness reproducibility (rCMT) among spectral-domain and time-domain optical coherence tomography (SD-OCT and TD-OCT) instruments.
Seventy-six eyes were imaged (44 normal, 32 maculopathy) either twice using four SD-OCT and one TD-OCT devices or three times using Spectralis SD-OCT (with and without eye tracking) (Heidelberg Engineering, Inc., Heidelberg, Germany). Cirrus images (Carl Zeiss Meditec, Dublin, CA) were further analyzed with three-point image registration.
All instruments had superior rCMT in normal versus pathologic eyes (P < .001). No difference in rCMT was noted among instruments in normal eyes (P = .92), but TD-OCT was superior to SD-OCT (P = .017) in pathologic eyes. Cirrus image registration improved rCMT for normal eyes (P = .04), with borderline improvement in pathologic eyes (P = .06). Spectralis eye tracking improved rCMT in normal (P = .01) and pathologic (P = .004) eyes.
Higher image resolution with SD-OCT may not improve rCMT, but image registration and eye tracking options may improve rCMT.
研究图像分辨率、眼动追踪及图像配准对光谱域和时域光学相干断层扫描（SD-OCT和TD-OCT）设备测量中心黄斑厚度重复性（rCMT）的影响。
76只眼睛接受成像检查（44只正常眼，32只患黄斑病变眼），分别使用四台SD-OCT设备和一台TD-OCT设备进行两次成像，或使用Spectralis SD-OCT（有或没有眼动追踪功能）（德国海德堡海德堡工程公司）进行三次成像。对Cirrus图像（美国加利福尼亚州都柏林卡尔·蔡司医疗技术公司）采用三点图像配准法进行进一步分析。
所有设备在正常眼与病变眼中均具有较好的rCMT（P <.001）。在正常眼中，各设备间rCMT无差异（P =.92），但在病变眼中，TD-OCT优于SD-OCT（P =.017）。Cirrus图像配准改善了正常眼的rCMT（P =.04），在病变眼中有临界改善（P =.06）。Spectralis眼动追踪功能改善了正常眼（P =.01）和病变眼（P =.004）的rCMT。
SD-OCT更高的图像分辨率可能不会改善rCMT，但图像配准和眼动追踪功能可能会改善rCMT。
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