Tepelus Tudor C, Hariri Amir H, Balasubramanian Siva, Sadda SriniVas R
Ophthalmic Surg Lasers Imaging Retina. 2018 Jun 1;49(6):410-415. doi: 10.3928/23258160-20180601-05.
To compare macular thickness measurement algorithms of two different spectral-domain optical coherence tomography (SD-OCT) devices in eyes affected by dry age-related macular degeneration (AMD).
Patients with dry AMD and healthy volunteers from the retina clinic of the Doheny Eye Center - UCLA were imaged using two different SD-OCT devices: the RS-3000 Advance (Nidek, Padova, Italy) and the Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA). All patients had been previously diagnosed with drusen or geographic atrophy due to AMD. The commercial instrument software was used to generate the macular retinal thickness measurements, and measurements were compared between devices.
Eighty-five diseased eyes from 49 patients and 16 healthy control eyes from eight normal volunteers were included in this study. The macular thickness measurements generated by the two instruments in eyes with AMD differed significantly in mean retinal thickness in the foveal center subfield (257.34 μm ± 51.72 μm using the Nidek OCT vs. 238.20 μm ± 51.89 μm using the Cirrus OCT; P < .001). The mean difference in macular thickness between the two devices was 19.14 μm ± 5.84 μm for diseased eyes and 17.06 μm ± 5.28 μm in normal control eyes, and this was not statistically different between the two groups (P > .05). The macular thickness measurements in diseased eyes, as evaluated by the two different instruments, however, showed excellent correlation (r = 0.99; P < .001), with an intraclass correlation coefficient of 0.99 (95% confidence interval, 0.98-0.99). Post hoc evaluation of cases with larger differences also showed differences in foveal center selection and variabilities in boundary selection with specific pathology.
Macular thickness measurements provided by the Nidek and Cirrus OCT instruments in eyes with dry AMD are highly correlated but show a consistent difference, which may allow the use of a standard correction factor to be applied to better interrelate measurements between the devices. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:410-415.].
比较两种不同光谱域光学相干断层扫描（SD - OCT）设备对干性年龄相关性黄斑变性（AMD）患者黄斑厚度的测量算法。
来自加州大学洛杉矶分校多希尼眼科中心视网膜门诊的干性AMD患者和健康志愿者使用两种不同的SD - OCT设备进行成像：RS - 3000 Advance（意大利帕多瓦尼德克公司）和Cirrus HD - OCT（加利福尼亚州都柏林卡尔蔡司医疗技术公司）。所有患者此前均因AMD被诊断为有玻璃膜疣或地图样萎缩。使用商业仪器软件生成黄斑视网膜厚度测量值，并对两种设备的测量结果进行比较。
本研究纳入了49例患者的85只患眼和8名正常志愿者的16只健康对照眼。两种仪器对AMD患者眼黄斑厚度的测量结果在黄斑中心凹子区域的平均视网膜厚度上存在显著差异（使用尼德克OCT测量为257.34μm±51.72μm，使用Cirrus OCT测量为238.20μm±51.89μm；P <.001）。两种设备对患眼黄斑厚度的平均差值为19.14μm±5.84μm，对正常对照眼为17.06μm±5.28μm，两组间差异无统计学意义（P>.05）。然而，两种不同仪器评估的患眼黄斑厚度测量结果显示出极好的相关性（r = 0.99；P <.001），组内相关系数为0.99（95%置信区间，0.98 - 0.99）。对差异较大病例的事后评估还显示，在黄斑中心凹选择以及特定病理情况下边界选择的变异性方面存在差异。
尼德克和Cirrus OCT仪器对干性AMD患者眼黄斑厚度的测量结果高度相关，但存在一致的差异，这可能允许使用标准校正因子来更好地关联两种设备之间的测量结果。[《眼科手术、激光与视网膜成像》。2018；49：410 - 415。]
