Luirink Joen, Yu Zhong, Wagner Samuel, de Gier Jan-Willem
Section of Molecular Microbiology, Department of Molecular Cell Biology, VU University, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.
Biochim Biophys Acta. 2012 Jun;1817(6):965-76. doi: 10.1016/j.bbabio.2011.12.006. Epub 2011 Dec 19.
The inner membrane proteome of the model organism Escherichia coli is composed of inner membrane proteins, lipoproteins and peripherally attached soluble proteins. Our knowledge of the biogenesis of inner membrane proteins is rapidly increasing. This is in particular true for the early steps of biogenesis - protein targeting to and insertion into the membrane. However, our knowledge of inner membrane protein folding and quality control is still fragmentary. Furthering our knowledge in these areas will bring us closer to understand the biogenesis of individual inner membrane proteins in the context of the biogenesis of the inner membrane proteome of Escherichia coli as a whole. This article is part of a Special Issue entitled: Biogenesis/Assembly of Respiratory Enzyme Complexes.
模式生物大肠杆菌的内膜蛋白质组由内膜蛋白、脂蛋白和外周附着的可溶性蛋白组成。我们对内膜蛋白生物合成的了解正在迅速增加。在生物合成的早期步骤——蛋白质靶向并插入膜中尤其如此。然而，我们对内膜蛋白折叠和质量控制的了解仍然支离破碎。在这些领域加深我们的认识将使我们更接近于在大肠杆菌内膜蛋白质组整体生物合成的背景下理解单个内膜蛋白的生物合成。本文是名为：呼吸酶复合物的生物合成/组装的特刊的一部分。
