苯乙烯基共轭香豆素笼状醇：通过单光子长波长或双光子近红外激发的高效光释放。

Styryl conjugated coumarin caged alcohol: efficient photorelease by either one-photon long wavelength or two-photon NIR excitation.

机构信息

Shanghai Key Laboratory of Functional Materials Chemistry, Institute of Fine Chemicals, East China University of Science and Technology, Shanghai, 200237, PR China.

出版信息

Org Lett. 2012 Jan 20;14(2):572-5. doi: 10.1021/ol203188h. Epub 2011 Dec 27.

DOI:10.1021/ol203188h

PMID:22201546

Abstract

The synthesis and photorelease properties of a new phototrigger for alcohols are described. Compared to ester 4 caged by the reported [7-(diethylamino)coumarin-4-yl]methoxycarbonyl (DEACM) phototrigger, the caged ester 3 shows an efficient single-photon photolysis efficiency upon irradiation of long wavelength light (λ = 475 nm) and a stronger two-photon photolysis sensitivity with 800 nm laser light. Its promising properties and the efficient photorelease of adenosine make it very useful as a caging group for biological applications.

摘要

本文描述了一种新型醇类光引发剂的合成及光解性质。与报道的 [7-(二乙氨基)香豆素-4-基]甲氧羰基（DEACM）光引发剂笼蔽的酯 4 相比，笼蔽酯 3 在长波长光（λ=475nm）照射下表现出高效的单光子光解效率，并且在 800nm 激光照射下具有更强的双光子光解灵敏度。其优良的性质和对腺苷的高效光释放使其非常适合作为生物应用的笼蔽基团。