Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, France.
Org Lett. 2012 Dec 21;14(24):6366-9. doi: 10.1021/ol3031704. Epub 2012 Dec 6.
The systematic SAR study of a "caging" group showed a strong influence of the position of the donor dimethylamino group on the efficiency of photolysis of the DMAQ (2-hydroxymethylene-(N,N-dimethylamino)quinoline) caged acetate under one-photon near-UV or two-photon near-IR excitation. Photorelease of l-glutamate by the most efficient 8-DMAQ derivative strongly and efficiently activated glutamate receptors, generating large, fast rising responses similar to those elicited by glutamate photoreleased from the widely used MNI-caged glutamate.
“笼锁”基团的系统 SAR 研究表明，供体二甲氨基的位置对 DMAQ（2-羟亚甲基-（N，N-二甲基氨基）喹啉）笼锁乙酸盐在单光子近 UV 或双光子近 IR 激发下光解效率有强烈影响。最有效的 8-DMAQ 衍生物的光释放谷氨酸强烈且有效地激活了谷氨酸受体，产生了类似于从广泛使用的 MNI-笼锁谷氨酸光释放的谷氨酸所引发的大、快速上升的反应。
