Department of Hepatobiliary and Transplant Surgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Curr Pharm Biotechnol. 2012 May;13(6):803-12. doi: 10.2174/138920112800399040.
Carbon monoxide is generally believed to be a 'toxic' gas molecule due to its binding capability with hemoglobin. Overexposure to carbon monoxide leads to a hypoxic state that may cause the death of a mammalian. In contrast, directly exposure of carbon monoxide may protect cells or organs from various disease insults. The paradox effects of carbon monoxide might vary on the ways of exposure and the amounts being exposed. Here we highlighted the characteristics of this gas molecule and summarized its protective effects and therapeutic potentials in liver diseases and liver transplantation.
一氧化碳通常被认为是一种“有毒”的气体分子，因为它能够与血红蛋白结合。过量的一氧化碳会导致缺氧状态，可能导致哺乳动物死亡。相比之下，一氧化碳的直接暴露可能会保护细胞或器官免受各种疾病的侵害。一氧化碳的这种矛盾效应可能因暴露方式和暴露量的不同而有所不同。在这里，我们强调了这种气体分子的特点，并总结了它在肝脏疾病和肝移植中的保护作用和治疗潜力。
