Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany.
Curr Pharm Biotechnol. 2012 May;13(6):797-802. doi: 10.2174/138920112800399130.
Although a potentially toxic gaseous molecule, carbon monoxide recently gains rising scientifically and clinical interest as its beneficial effects and mechanisms of action are defined substantially in various in vitro and in vivo experiments. Its anti-inflammatory, anti-apoptotic and anti-proliferative properties but its increasing impact concerning numerous disease models in means of protection, well describe this gas as a new and challenging therapeutic alternative. In this review, we focus on the extensively analyzed advantageous value of pre- and postconditioning with inhaled carbon monoxide in the context of lung and kidney injury, induced by the low perfusion during and after cardiopulmonary bypass. Mechanisms like the heat shock response as well as an expanded view regarding toxicity and side effects are described broadly.
尽管一氧化碳是一种潜在的有毒气体分子，但随着其在各种体外和体内实验中有益作用和作用机制的大量确定，它最近引起了科学界和临床界越来越多的兴趣。它具有抗炎、抗细胞凋亡和抗增殖特性，但在通过心肺转流期间和之后的低灌注导致的肺和肾损伤等多种疾病模型中，其影响不断增加，这充分说明了这种气体是一种新的、具有挑战性的治疗选择。在这篇综述中，我们重点分析了吸入一氧化碳预处理和后处理在心肺转流期间和之后的低灌注导致的肺和肾损伤中的有利价值，讨论了热休克反应等机制，以及关于毒性和副作用的更广泛的观点。
