变应性鼻炎中的FOXP3和转化生长因子-β基因多态性
FOXP3 and TGF-β gene polymorphisms in allergic rhinitis.
作者信息
Hassannia Hadi, Abediankenari Saeid, Ghaffari Javad
机构信息
Department of Immunology and Microbiology, Mazandaran University of Medical Sciences, Sari, Iran, e-mail:
出版信息
Iran J Immunol. 2011 Dec;8(4):218-25.
BACKGROUND
Regulatory CD4+ T (Treg) cells are effective in maintaining immune tolerance.
OBJECTIVE
To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR).
METHODS
Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated in AR patients and compared with controls. In a case-control study, 155 AR patients and 163 allergy-free controls were genotyped using polymerase chain reaction sequence-specific primer (PCR-SSP) technique.
RESULTS
The analysis of the frequency of these SNPs showed that the haplotype formed by FOXP3 -3279 A allele occurred significantly more frequently in patients than controls (odds ratio=1.44, 95% CI=1.312-2.66; p=0.001).
CONCLUSION
Our results suggest that polymorphism in FOXP3 gene is associated with susceptibility to AR.
背景
调节性CD4 + T（Treg）细胞在维持免疫耐受方面有效。
目的
研究伊朗变应性鼻炎（AR）患者中转化生长因子β-1（TGF-β1）和叉头框蛋白3（FOXP3）基因的单核苷酸多态性（SNP）。
方法
评估AR患者中TGF-β1第10和25密码子以及FOXP3基因-3279 A>C和-924 A>G位点的变异，并与对照组进行比较。在一项病例对照研究中，采用聚合酶链反应序列特异性引物（PCR-SSP）技术对155例AR患者和163例无过敏对照进行基因分型。
结果
这些SNP频率分析显示，由FOXP3 -3279 A等位基因形成的单倍型在患者中出现的频率显著高于对照组（优势比=1.44，95%可信区间=1.312 - 2.66；p = 0.001）。
结论
我们的结果表明，FOXP3基因多态性与AR易感性相关。
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