Cap R, Lüscher K P
Frauenklinik Kantonsspital Münsterlingen.
Zentralbl Gynakol. 1990;112(12):773-8.
A 32 year old I P II G with preexisting diabetes insipidus was treated with 1-(3-mercaptopropionic acid)-8-d-arginine vasopressin (DDAVP) during pregnancy. An otherwise normal pregnancy was marked only with an excessive weight increase. A healthy girl was delivered by secondary cesarean section at term. Postoperative the mother developed a water intoxication accompanying oxytocin-infusion. During nursing the diabetes insipidus improved significantly whereby DDAVP doses could be reduced to 20-10 percent. We suppose an overreaction to endogene oxytocin with an antidiuretic effect.
一名32岁、既往患尿崩症的初产妇，孕1产0，孕期使用1-(3-巯基丙酸)-8-D-精氨酸加压素（去氨加压素）治疗。孕期除体重过度增加外，其他情况正常。足月时经二次剖宫产分娩一健康女婴。术后母亲在输注缩宫素时发生水中毒。哺乳期间尿崩症明显改善，去氨加压素剂量可减至20% - 10%。我们推测是对具有抗利尿作用的内源性缩宫素反应过度。
