造血干细胞龛。
The hematopoietic stem cell niche.
机构信息
Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
出版信息
Front Biosci (Landmark Ed). 2012 Jan 1;17(1):30-9. doi: 10.2741/3913.
Abstract
Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC niche is a goal of basic scientists and clinicians alike. Recent studies have focused on defining the cellular components and molecular factors critical to this microenvironment. Here we review recent findings, discuss unresolved questions, and examine the clinical implications of our current knowledge of the HSC niche.
摘要
造血干细胞（HSCs）具有自我更新的能力，并能沿着多种不同的造血谱系分化为成熟的后代。HSCs 的功能取决于其周围细胞的信号，这些细胞位于高度特化的微环境中，称为造血干细胞龛。理解和利用 HSC 龛是基础科学家和临床医生的共同目标。最近的研究集中在定义对这个微环境至关重要的细胞成分和分子因子上。在这里，我们回顾最近的发现，讨论未解决的问题，并研究我们目前对 HSC 龛的知识的临床意义。
相似文献
1
The hematopoietic stem cell niche.
Front Biosci (Landmark Ed). 2012 Jan 1;17(1):30-9. doi: 10.2741/3913.
2
Regulation of hematopoietic stem cells in the niche.
Sci China Life Sci. 2015 Dec;58(12):1209-15. doi: 10.1007/s11427-015-4960-y. Epub 2015 Nov 13.
3
The HSC niche concept has turned 31. Has our knowledge matured?
Ann N Y Acad Sci. 2010 Mar;1192:12-8. doi: 10.1111/j.1749-6632.2009.05223.x.
4
The hematopoietic stem-cell niche in health and leukemia.
Cell Mol Life Sci. 2017 Feb;74(4):579-590. doi: 10.1007/s00018-016-2306-y. Epub 2016 Jul 19.
5
Microenvironmental regulation of hematopoietic stem cells and its implications in leukemogenesis.
Curr Opin Hematol. 2016 Jul;23(4):339-45. doi: 10.1097/MOH.0000000000000251.
6
Current world literature.
Curr Opin Hematol. 2010 Jul;17(4):375-86. doi: 10.1097/MOH.0b013e32833bbf8c.
7
Minireview: complexity of hematopoietic stem cell regulation in the bone marrow microenvironment.
Mol Endocrinol. 2014 Oct;28(10):1592-601. doi: 10.1210/me.2014-1079. Epub 2014 Aug 1.
8
Bone, microenvironment and hematopoiesis.
Curr Opin Hematol. 2012 Jul;19(4):250-5. doi: 10.1097/MOH.0b013e328353c714.
9
The evolving view of the hematopoietic stem cell niche.
Exp Hematol. 2017 Jun;50:22-26. doi: 10.1016/j.exphem.2017.01.008. Epub 2017 Feb 9.
10
The functional interplay between systemic cancer and the hematopoietic stem cell niche.
Pharmacol Ther. 2016 Dec;168:53-60. doi: 10.1016/j.pharmthera.2016.09.006. Epub 2016 Sep 2.
引用本文的文献
1
Characteristics of the cancer stem cell niche and therapeutic strategies.
Stem Cell Res Ther. 2022 Jun 3;13(1):233. doi: 10.1186/s13287-022-02904-1.
2
Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways.
Theranostics. 2021 Jun 22;11(16):7735-7754. doi: 10.7150/thno.60757. eCollection 2021.
3
Spelling Out CICs: A Multi-Organ Examination of the Contributions of Cancer Initiating Cells' Role in Tumor Progression.
Stem Cell Rev Rep. 2022 Jan;18(1):228-240. doi: 10.1007/s12015-021-10195-x. Epub 2021 Jul 9.
4
Hematopoietic Multipotent Progenitors and Plasma Cells: Neighbors or Roommates in the Mouse Bone Marrow Ecosystem?
Front Immunol. 2021 Apr 15;12:658535. doi: 10.3389/fimmu.2021.658535. eCollection 2021.
5
Synthetic biology for improving cell fate decisions and tissue engineering outcomes.
Emerg Top Life Sci. 2019 Nov 11;3(5):631-643. doi: 10.1042/ETLS20190091.
6
The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis.
Int J Mol Sci. 2020 Jul 14;21(14):4967. doi: 10.3390/ijms21144967.
7
The Endosteal Niche in Breast Cancer Bone Metastasis.
Front Oncol. 2020 Mar 13;10:335. doi: 10.3389/fonc.2020.00335. eCollection 2020.
8
Bioactivity of CD34+ cells in patients with acute-on-chronic liver failure.
Int J Clin Exp Pathol. 2017 Nov 1;10(11):10781-10791. eCollection 2017.
9
Long Non-coding RNAs in Myeloid Malignancies.
Front Oncol. 2019 Oct 18;9:1048. doi: 10.3389/fonc.2019.01048. eCollection 2019.
10
The bone metastasis niche in breast cancer-potential overlap with the haematopoietic stem cell niche .
J Bone Oncol. 2019 Jun 7;17:100244. doi: 10.1016/j.jbo.2019.100244. eCollection 2019 Aug.
本文引用的文献
1
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
Nat Med. 2010 Oct;16(10):1141-6. doi: 10.1038/nm.2217. Epub 2010 Sep 26.
2
The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.
Immunity. 2010 Sep 24;33(3):387-99. doi: 10.1016/j.immuni.2010.08.017.
3
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.
Nature. 2010 Aug 12;466(7308):829-34. doi: 10.1038/nature09262.
4
Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.
Nature. 2010 Jun 10;465(7299):793-7. doi: 10.1038/nature09135.
5
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.
Nature. 2010 Apr 8;464(7290):852-7. doi: 10.1038/nature08851. Epub 2010 Mar 21.
6
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.
Cell Stem Cell. 2010 Mar 5;6(3):251-64. doi: 10.1016/j.stem.2010.02.001.
7
Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.
Nat Biotechnol. 2010 Mar;28(3):275-80. doi: 10.1038/nbt.1607. Epub 2010 Feb 14.
8
Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model.
Blood. 2009 Nov 12;114(20):4402-10. doi: 10.1182/blood-2008-12-196311. Epub 2009 Sep 16.
9
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.
Nature. 2009 Jul 9;460(7252):259-63. doi: 10.1038/nature08099. Epub 2009 Jun 10.
10
IFN-alpha wakes up sleeping hematopoietic stem cells.
Nat Med. 2009 Jun;15(6):612-3. doi: 10.1038/nm0609-612.
Zotero 插件