Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.
Front Biosci (Landmark Ed). 2012 Jan 1;17(1):30-9. doi: 10.2741/3913.
Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to mature progeny along multiple different hematopoietic lineages. The function of HSCs depends upon the signals from surrounding cells found within the highly specialized microenvironment termed the hematopoietic stem cell niche. Understanding and exploiting the HSC niche is a goal of basic scientists and clinicians alike. Recent studies have focused on defining the cellular components and molecular factors critical to this microenvironment. Here we review recent findings, discuss unresolved questions, and examine the clinical implications of our current knowledge of the HSC niche.
造血干细胞（HSCs）具有自我更新的能力，并能沿着多种不同的造血谱系分化为成熟的后代。HSCs 的功能取决于其周围细胞的信号，这些细胞位于高度特化的微环境中，称为造血干细胞龛。理解和利用 HSC 龛是基础科学家和临床医生的共同目标。最近的研究集中在定义对这个微环境至关重要的细胞成分和分子因子上。在这里，我们回顾最近的发现，讨论未解决的问题，并研究我们目前对 HSC 龛的知识的临床意义。
