Department of Pathology, Yonsei University College of Medicine, Seoul 03722, Korea.
Department of Pathology, Yonsei University College of Medicine, Severance Hospital, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
Int J Mol Sci. 2020 Jul 14;21(14):4967. doi: 10.3390/ijms21144967.
The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review.
乳腺癌的发病率和死亡率主要归因于远处转移，尤其是骨转移。许多因素可能导致乳腺癌发生骨转移，但肿瘤细胞与其他周围类型的细胞之间的相互作用，以及它们共同分泌的细胞因子，预计将发挥最重要的作用。骨髓脂肪细胞（BMA）是构成骨骼的细胞类型之一，脂肪细胞因子是乳腺癌细胞和 BMAs 共同分泌的细胞因子之一。这些 BMAs 和脂肪细胞因子已知与癌症进展有关，本综述重点关注 BMAs 和脂肪细胞因子在乳腺癌骨转移过程中的作用。本综述还探讨了它们作为抑制骨转移的潜在靶点的可能性。
