Department of Carcinogenesis, Science Park Research Division, MD Anderson Cancer Center, Smithville, Texas 78957, USA.
Front Biosci (Landmark Ed). 2012 Jan 1;17(3):970-5. doi: 10.2741/3967.
ATP-dependent chromatin remodeling complexes are involved in several nuclear processes. In particular the INO80 remodeling complex is an essential factor during transcription and DNA repair. Recently, several labs have described a novel role for INO80 during DNA replication. Moreover, Falbo et al. have presented evidence linking INO80's activities to the DNA damage tolerance pathways during replication (1). In this review we will discuss and integrate the results obtain by these various research groups to describe a novel role for INO80 in DNA replication.
ATP 依赖的染色质重塑复合物参与了许多核过程。特别是 INO80 重塑复合物是转录和 DNA 修复过程中的一个必需因素。最近,几个实验室已经描述了 INO80 在 DNA 复制过程中的一个新角色。此外,Falbo 等人提出了证据,将 INO80 的活性与复制过程中的 DNA 损伤耐受途径联系起来(1)。在这篇综述中,我们将讨论和整合这些不同研究小组的结果,以描述 INO80 在 DNA 复制中的一个新角色。