Conaway Ronald C, Conaway Joan Weliky
Stowers Institute for Medical Research, Kansas City, MO 64110, USA; Department of Biochemistry and Molecular Biology, Kansas University Medical Center, Kansas City, KS 66160, USA.
Trends Biochem Sci. 2009 Feb;34(2):71-7. doi: 10.1016/j.tibs.2008.10.010. Epub 2008 Dec 6.
The Ino80 ATPase is a member of the SNF2 family of ATPases and functions as an integral component of a multisubunit ATP-dependent chromatin remodeling complex. Although INO80 complexes from yeast and higher eukaryotes share a common core of conserved subunits, the complexes have diverged substantially during evolution and have acquired new subunits with apparently species-specific functions. Recent studies have shown that the INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication.
INO80 ATP酶是ATP酶SNF2家族的成员，作为多亚基ATP依赖的染色质重塑复合体的一个组成部分发挥作用。尽管来自酵母和高等真核生物的INO80复合体共享一个保守亚基的共同核心，但这些复合体在进化过程中已发生了显著分化，并获得了具有明显物种特异性功能的新亚基。最近的研究表明，INO80复合体参与多种依赖染色质的核事务，包括转录、DNA修复和DNA复制。
