Department of Ophthalmology, Shanghai Jiaotong University Affiliated First People's Hospital, Shanghai, China, 200080.
Front Biosci (Landmark Ed). 2012 Jan 1;17(4):1461-8. doi: 10.2741/3997.
Recent studies have revealed that melatonin exerts strong anti-apoptotic effects. Retina secretes melatonin, and melatonin receptors are distributed in almost all the layers of retina, including the layer of retinal pigment epithelial (RPE) cells. However, it is not known whether melatonin inhibits apoptosis through its anti-oxidant effects and how it works in RPE cells. Here, we show that melatonin decreases H2O2-induced apoptosis in RPE cells partially through protection of mitochondria. Melatonin decreased reactive oxygen species in mitochondria and mitochondrial DNA damage, alleviated structural damage and inhibited cytochrome C release.
最近的研究表明，褪黑素具有很强的抗细胞凋亡作用。视网膜分泌褪黑素，而褪黑素受体几乎分布在视网膜的所有层中，包括视网膜色素上皮（RPE）细胞层。然而，褪黑素是否通过其抗氧化作用抑制细胞凋亡以及在 RPE 细胞中如何发挥作用尚不清楚。在这里，我们表明褪黑素通过保护线粒体部分抑制 H2O2 诱导的 RPE 细胞凋亡。褪黑素减少线粒体中的活性氧和线粒体 DNA 损伤，减轻结构损伤并抑制细胞色素 C 的释放。
