Kim Kibeom, Yoon Seongyong, Kim Jinseok, Woo Kuck-Hyun, Cho Seong-Yong, Jo Ha-Ram
Department of Occupational and Environmental Medicine, Soonchunhyang University Gumi Hospital, Gumi, Korea.
Ann Occup Environ Med. 2021 Feb 8;33:e7. doi: 10.35371/aoem.2021.33.e7. eCollection 2021.
Age-related macular degeneration (AMD) is the leading cause of blindness. Shift work has well-known adverse effects on health. However, few studies have investigated the relationship between shift work and AMD. This study was conducted to investigate the relationship between shift work and AMD.
This study used aggregated data from the 2010-2012 cycles of the Korea National Health and Nutrition Examination Survey. The work schedules were classified into 2 types: day work and shift work. AMD was determined using fundus photographs. The χ test and multiple logistic regression analysis were used to assess sex-stratified relationship between shift work and AMD.
The odds ratio (OR) of AMD in male shift workers was higher (1.54 [95% confidence interval, CI: 1.01-2.36]) than that in male day workers after adjusting for covariates. After dividing into subgroups of the shift work pattern, the OR of AMD in male night shift workers was higher (1.75 [95% CI: 1.07-2.85]) than that in male day workers after adjusting for covariates. However, results of the female worker group were not significant.
The results of this study provide limited support for the hypothesis that shift work is related to AMD. Further prospective studies are needed to define the relationship between shift work and AMD.
年龄相关性黄斑变性（AMD）是导致失明的主要原因。轮班工作对健康有众所周知的不利影响。然而，很少有研究调查轮班工作与AMD之间的关系。本研究旨在调查轮班工作与AMD之间的关系。
本研究使用了韩国国家健康与营养检查调查2010 - 2012周期的汇总数据。工作时间表分为两种类型：日班工作和轮班工作。使用眼底照片确定AMD。χ检验和多元逻辑回归分析用于评估轮班工作与AMD之间的性别分层关系。
在调整协变量后，男性轮班工作者患AMD的优势比（OR）高于男性日班工作者（1.54 [95%置信区间，CI：1.01 - 2.36]）。在将轮班工作模式分为亚组后，调整协变量后，男性夜班工作者患AMD的OR高于男性日班工作者（1.75 [95% CI：1.07 - 2.85]）。然而，女性工作者组的结果不显著。
本研究结果为轮班工作与AMD相关这一假设提供了有限的支持。需要进一步的前瞻性研究来确定轮班工作与AMD之间的关系。
