Ledesma Maria Dolores, Dotti Carlos Gerardo
Center for Molecular Biology Severo Ochoa CSIC-UAM, Madrid, Spain.
Front Biosci (Elite Ed). 2012 Jan 1;4(1):181-94. doi: 10.2741/e368.
Strong correlations have been made between high levels of blood cholesterol and the risk to suffer Alzheimer's disease (AD). The question arises on how a peripheral event contributes to a disease that so severely affects the integrity and function of the Central Nervous System. Hypercholesterolemia has been also associated to peripheral metabolic disorders like diabetes, obesity or atherosclerosis that, in turn, predispose to AD. Here we review data, which point to alterations in blood cholesterol levels as a link between these metabolic disorders and AD. We describe and discuss common, cholesterol-related, molecular mechanisms and strategies to fight these conditions that, altogether, constitute a major cause of death in our societies.
血液中高水平的胆固醇与患阿尔茨海默病（AD）的风险之间存在很强的相关性。一个问题随之而来：一个外周事件是如何导致一种严重影响中枢神经系统完整性和功能的疾病的。高胆固醇血症还与糖尿病、肥胖症或动脉粥样硬化等外周代谢紊乱有关，而这些疾病反过来又易引发AD。在这里，我们回顾了相关数据，这些数据表明血液胆固醇水平的改变是这些代谢紊乱与AD之间的一个联系。我们描述并讨论了常见的、与胆固醇相关的分子机制以及对抗这些疾病的策略，这些疾病共同构成了我们社会中的主要死因。
