Giordano Vincenzo, Peluso Gianfranco, Iannuccelli Maurizio, Benatti Paola, Nicolai Raffaella, Calvani Menotti
Scientific Department, Sigma-Tau, Via Pontina km 30,400, Pomezia, Rome, Italy.
Neurochem Res. 2007 Apr-May;32(4-5):555-67. doi: 10.1007/s11064-006-9125-8. Epub 2006 Aug 17.
Since its definition Alzheimer's disease has been at the centre of consideration for neurologists, psychiatrists, and pathologists. With John P. Blass it has been disclosed a different approach Alzheimer's disease neurodegeneration understanding not only by the means of neurochemistry but also biochemistry opening new scenarios in the direction of a metabolic system degeneration. Nowadays, the understanding of the role of cholesterol, insulin, and adipokines among the others in Alzheimer's disease etiopathogenesis is clarifying approaches valuable not only in preventing the disease but also for its therapy.
自阿尔茨海默病被定义以来，它一直是神经学家、精神科医生和病理学家关注的核心。与约翰·P·布拉斯一起，人们发现了一种不同的理解阿尔茨海默病神经退行性变的方法，不仅通过神经化学手段，还通过生物化学，为代谢系统退化的方向开辟了新的前景。如今，对胆固醇、胰岛素和脂肪因子等在阿尔茨海默病病因发病机制中的作用的理解，正在阐明不仅对预防该疾病而且对其治疗都有价值的方法。
