Fukuda Michiko N, Sugihara Kazuhiro
Tumor Microenvironment Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA.
Front Biosci (Elite Ed). 2012 Jan 1;4(1):342-50. doi: 10.2741/381.
The process of human embryo implantation is mediated not only by evolutionarily conserved mechanisms but by activities unique to humans. Among the latter, evidence suggests that the cell adhesion molecule trophinin plays a unique role in human embryo implantation. Here, we describe characteristics of trophinin protein and of the trophinin-associated proteins bystin and tastin. We then describe trophinin-mediated signal transduction in trophectoderm cells during human embryo implantation and events related to human sperm tail motility. We also report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others.
人类胚胎着床过程不仅由进化上保守的机制介导，还由人类特有的活动介导。在后者中，有证据表明细胞粘附分子滋养层蛋白在人类胚胎着床中发挥独特作用。在此，我们描述了滋养层蛋白以及与滋养层蛋白相关的蛋白bystin和tastin的特征。然后，我们描述了人类胚胎着床期间滋养层蛋白介导的滋养外胚层细胞信号转导以及与人类精子尾部运动相关的事件。我们还报告了滋养层蛋白在人类癌症中的双重作用，即在某些肿瘤类型中促进恶性肿瘤发展，而在其他肿瘤类型中抑制恶性肿瘤发展。
